Compared to the CHD control group, the CHD + HT + T2DM group showed enhanced effects of SIX1 (transcription factor) and reduced activities of DMD (human dystrophin gene), MYOD1 (transcription factor), MEF2C (transcription factor), and beta-estradiol (sex hormone; Suppl. The gene discussed is SIX1; the disease is type 2 diabetes mellitus.