When comparing CHD to CHD + HT + T2DM, we detected four subnetworks containing either growth factors (TGFB1, PGF, PDGFB, etc.), chemokines (CCL2, CCL3, etc.)or cell surface proteins (TNF receptors, PDCD1, CD5, etc.). This evidence concerns the gene TGFB1 and type 2 diabetes mellitus.