When comparing CHD to CHD + HT + T2DM, we detected four subnetworks containing either growth factors (TGFB1, PGF, PDGFB, etc.), chemokines (CCL2, CCL3, etc.)or cell surface proteins (TNF receptors, PDCD1, CD5, etc.). The gene discussed is PDGFB; the disease is coronary artery disorder.