For LDH, the standard prognostic score IPI has included LDH in the prognosis stratification of DLBCL patients, and high LDH indicates poor prognosis [18, 27].For β2 microglobulin, some studies have shown that β2 microglobulin can identify subsets with poor prognosis in intermediate-risk patients with DLBCL [28] and may improve NCCN-IPI score [29]. The gene discussed is HLA-G; the disease is diffuse large B-cell lymphoma.