In ovarian cancer, many immune suppression mechanisms have been identified: CD8+ T cell suppression by regulatory T cells (Tregs), IL-10 and IL-6 mediated upregulation of inhibitory receptor PD-1 on tumour infiltrating CD8+ T cells, as well as the presence of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumour-associated macrophages (TAMs), and cancer-associated fibroblasts [6, 22–24]. This evidence concerns the gene CD8A and cancer.