Studies of B7-H3 CAR T cells in NOD-scid IL2Rgammanull (NSG) mice demonstrated anti-tumor activity against xenograft models of high B7-H3 expressing prostate cancer, pulmonary giant cell carcinoma, subcutaneous ovarian carcinoma and osteosarcoma [17, 26–29]. Here, CD276 is linked to Familial prostate cancer.