Moreover, lymph node metastasis (yes vs no, HR 2.403, 95% CI 1.149–5.026, P < 0.05, Fig. 4m) and PLIN3 in fibroblasts (high vs low, HR 2.615, 95% CI 1.260–5.428, P < 0.05, Fig. 4m) could be used as independent prognostic factors for OS and DFS of OSCC in the multivariable models. This evidence concerns the gene PLIN3 and metastatic malignant neoplasm in the lymph nodes.