Interestingly, OSCC patients with PLIN3high tumor cells exhibited a higher Ki-67 positivity (Fig. 1f) contrary to immunocytes (Fig. 1G), and we speculate that PLIN3 was as important as LDs for the growth of tumor cells, but also indispensable for immune cells in the activation of CD8+ T lymphocytes [32, 33]. This evidence concerns the gene MKI67 and neoplasm.