Thus, we divided OSCC patients into different subpopulations based on PLIN3 and B7-H2 expression, and OSCC patients with high PLIN3+B7-H2+ tumor cells had significantly shorter OS and DFS (Fig. 6i, j) and harbored less absolute count of CD3+CD8+ and CD3+CD4+ T cell infiltration in peripheral blood (Fig. 6k, l). This evidence concerns the gene ICOSLG and neoplasm.