TARDBP and proteostasis deficiencies: There are some hints for pathomechanistic links between TDP-43 proteinopathies (comprising e.g. familial FTLD with TDP-43 pathology (FTLD-TDP), caused by mutations in GRN or C9orf72 hexanucleotide repeat expansion) and tauopathies, as e.g. the TAU tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43 [244].