Despite parallels concerning cognitive impairment and cellular pathology of NPC and AD, genetic variants and polymorphisms in NPC1 and NPC2 are not directly associated with elevated AD risk in the Chinese population [169], and NPC1/2 variants did not confer susceptibility for several Tauopathies (PD, FTLD-TAU, PSP) [170, 171]. This evidence concerns the gene NPC1 and Alzheimer disease.