Notably, after knocking down STAT6 in macrophages, the expression of CD206 stimulated by IL-4 was not reduced by 23-HBA, and 23-HBA failed to inhibit the activation of the IL-10/STAT3/Bcl-2 signaling pathway induced by M2 macrophages and the resulting resistance to 5-FU in cancer cells. The gene discussed is STAT3; the disease is cancer.