Further, different MANNosylation strategies of MSNs were developed to utilize the biological activity of the sugar in combination with different chemical linkage to look at the already well‐studied mannose‐binding adhesins, which is essential for potential applications such as coatings of biomedical devices.[20, 21, 22, 23, 24] To investigate the biocompatibility of the different formulations, we verified their cytotoxic potential in T24 bladder cancer cells and explored the response of crucial components of the inflammatory cascade, namely TLR4 and the transcription factor NF‐κB. This evidence concerns the gene NFKB1 and urinary bladder cancer.