Pneumonitis, fatigue, anemia, AST increased, hypophysitis, thrombocytopenia, adrenocortical insufficiency, asthenia, diarrhea, colitis, acute kidney injury/nephritis, rash, neutrophil count decreased, ALT increased, and mucosal inflammation were the uncommon trAEs for grade three or more; however, the other reported specific trAEs were rare (<0.1%, ≥0.01%) or very rare (<0.01%). The gene discussed is GPT; the disease is hypophysitis.