IFN‐α induces TNF‐Related Apoptosis‐Inducing Ligand (TRAIL) expression in bladder cancer cells36, 47 and triggers apoptosis in cells expressing the appropriate cell death receptor, by Fas‐associated death‐domain‐ (FADD‐) dependent activation of caspase‐8.19, 34. This evidence concerns the gene FADD and urinary bladder cancer.