TNF and type 2 diabetes mellitus: Accordingly, BM-CD34+ HSPCs from T2DM patients showed, besides SETD7 upregulation, a SASP profile characterized by the overexpression of p21, p27, NFkB-p65, and NFkB target TNFα/IL-6 genes, demonstrating that T2DM is a powerful driver of organismal aging which also includes stem cells [55].