In line with our in vitro model of hyperglycemia, at the end of differentiation, CAD-T2DM-derived monocytes still showed, as their precursors, high expression levels of CDKi p21 and p27 genes, and release, after LPS stimulation, of proinflammatory IL6 and TNFα cytokines (Fig. 7E–G). This evidence concerns the gene TNF and type 2 diabetes mellitus.