TNF and type 2 diabetes mellitus: Consistent with our in vitro model of hyperglycemia, CD34+ cells from CAD-T2DM patients displayed, a significant upregulation of CDKi p21 and p27 genes (Fig. 6A and B) as well as upregulation of proinflammatory genes (IL6 and TNFα), and their transcription factor NFkB-p65 (Fig. 6C and E).