STING1 and neoplasm: To examine the prolonged prophylactic effect of the extended lifetime of the memory-like NK cells induced by two cycles of the combination therapy, we employed a prophylactic protocol setting in which two cycles of either the PBS, the STING-LNPs, the CpG-ODNs, or the combination therapy was intravenously administered on days 0 and 4 followed by tumor inoculation on day 24.