Specifically, the ceramide lipids increased in T2D were 1-deoxyceramides (i.e., Cer(m18:1_22:0), Cer(m18:0_22:0), Cer(m18:1_23:0), Cer(m18:0_23:0), Cer(m18:0_24:1) and Cer(m18:0_24:0)) (Fig. 2). This evidence concerns the gene CBLN1 and type 2 diabetes mellitus.