Our results revealed an increase of a set of 1-deoxyceramides, Cer(m18:1_22:0), Cer(m18:0_22:0), Cer(m18:1_23:0), Cer(m18:0_23:0), Cer(m18:0_24:1), Cer(m18:0_24:0), in subjects with T2D compared to subjects with T1D and controls. The gene discussed is CBLN1; the disease is type 2 diabetes mellitus.