SRC-1 can enhance angiogenesis mediated by basic fibroblast growth factor (bFGF) in vivo to promote glioma progression; in addition, SRC-1 binds with polyoncovirusenhancer activator 3 (PEA3) to promote the transcription of its target genes VEGF and MMP-9, regulating endothelial cell (EC) function and promoting angiogenesis [93]. The gene discussed is FGF2; the disease is central nervous system cancer.