In the past 30 years, more than 300 transcriptional coactivators have been reported [14], and as an early identified coactivator, SRC-1 has been widely shown to play roles in various biological and pathological processes, including lipid metabolism and transport, neuronal synaptic plasticity, energy homeostasis, vascular endothelial injury, inflammation, diabetes progression, and tumorigenesis. Here, SRC is linked to diabetes mellitus.