PPARGC1A and obesity due to melanocortin 4 receptor deficiency: Genetic deletion of SRC-2 reduced the activity of PPARγ, suppressed white adipose accumulation and accelerated the thermogenesis of PGC-1 in brown adipose tissue by promoting the interaction between SRC-1 and PGC-1α, whereas genetic deletion of SRC-1 triggered energy metabolic dysfunction and obesity [23].