CD274 and neoplasm: In light of the crucial role of immune escape by tumor cells, tumor angiogenesis, and ECM, a novel self-delivery photothermal-boosted-nanoformulation was developed involving NIR-II activated BP tandem-augmented Anti-PD-L1 mAb plus SF to remodel the TIME and convert "cold" tumors into "hot" ones for achieving optimal ICIs therapy efficacy.