Inhalation of curcumin-NPs (50 μg/kg, 100 μg/kg, and 200 μg/kg) for 21 consecutive days significantly improved BLM-induced PF, as determined by a decrease in pulmonary inflammatory cell infiltration, lower levels of pulmonary hydroxyproline and cytokines (Tumor Necrosis Factor-alpha [TNF-α], Interleukin-10 [IL-10], and platelet-derived growth factor [PDGF]). This evidence concerns the gene IL10 and pemphigus foliaceus.