NFKB1 and intervertebral disk degenerative disorder: Circ-FAM169A promotes IDD by regulating NF-κB pathway-induced IL-1β and TNF-α production via the miR-583/BTRC signaling pathway, upregulating the expression of MMP13 and ADAMTS5, and downregulating the expression of collagen II and aggrecan (Guo et al. 2020).