Therefore, we selected three apoptosis-related (Bcl-2, Bcl2-L-4, and Caspase-3) and five cell cycle-related (Rb, p53, p27Kip1, p16INK4, and PCNA) antibodies further to explore the prognostic significance of those proteins in ESCC. This evidence concerns the gene BCL2 and esophageal squamous cell carcinoma.