Interestingly, several upregulated genes in kdAGC1 are also upregulated in Alzheimer’s disease, such as ITAG5, BGN, FAT3, TAP1 (transporter 1 ATP-binding cassette), KCNT2 (potassium channel subfamily T member 2), EFCAB1 (EF-hand calcium-binding domain-containing protein 1), and PSMB9 (proteasome subunit beta type-9) [75, 76]. Here, BGN is linked to early-onset autosomal dominant Alzheimer disease.