ASPA and Canavan disease: Along with their downregulation, even the fatty-acid synthase FASN, a key enzyme that catalyzes the addition of acetyl-CoA to malonyl-CoA to form palmitate [83], and ASPA, encoding the enzyme catalyzing the conversion of NAA to aspartate and acetate, whose impairment is linked to the neurological Canavan disease [84], are downregulated, although the western blot analysis has limitations for FASN antibody.