CD8A and neoplasm: In vivo experiments showed that pan-caspase inhibitors such as Zvad-fmk and IDN-6556 (F-03491390) induced apoptosis (and also necroptosis) in a multimodal tumor therapy with radiotherapy (RT), dacarbazine (DTIC), and hyperthermia (HT) combined with drugs, resulting in significant anti-tumor immunity, which was manifested by markedly increased infiltration of DCs and CD8+ T-cell, increased expression of IFN-γ of CD8+ T cells and reduced tumor infiltration of regulatory T cells, which together serve to inhibit tumor growth [135].