GSDMD and neoplasm: Another example is that chemotherapeutic agent cisplatin (DDP) can work as an anti-tumor agent for triple-negative breast cancer (TNBC), which induce pyroptosis to exert anti-tumor effects in vivo and vitro by up-regulation of the maternally expressed gene 3 (MEG3) and activation of the NLRP3/caspase-1/GSDMD signaling pathway to, thus improving the rate of pathological complete remission in TNBC patients, and providing new sights into the development of strategies for therapeutic interventions in TNBC [138].