IL10 and systemic lupus erythematosus: We report that in addition to a decrease in IL-10+ Breg cells in a new SLE patient cohort (demographics are reported in Table 1) (Fig. 7a), B cells from patients with SLE present with significantly greater mitochondrial membrane depolarization and elevated mitochondrial ROS levels compared with healthy donor B cells ex vivo (Extended Data Fig. 9a) or following CpGC stimulation (Fig. 7b–d).