We confirmed that in B cells from patients with SLE, rhTrx restored the production of IL-10 by all B cell subsets, including CD24hiCD38hi immature, CD24intCD38int mature-naive and CD24+CD38lo memory B cells and CD24lo/−CD38hi plasmablasts (Extended Data Fig. 10a). Here, IL10 is linked to systemic lupus erythematosus.