We evaluated pain parameters in relation to: (i) pain not explained by other known conditions (subscore of NMSS item 27), (ii) sensory complaints related to parkinsonism (subscore of UPDRS-II item 17), (iii) bodily discomfort (subscore of PDQ-39), and the expression of beta-endorphin in the cerebrospinal fluid (CSF), before and six months after DBS implantation. The gene discussed is POMC; the disease is Parkinsonism.