This further unleash the tumoricidal activity of tumor-infiltrating CD8+ T cells, evidenced by the highest frequencies of tumor-reactive (IFN-γ+) CD8+ T cells in P-BS-CM1 → P-PS-CM2 (+) treated tumors compared to the P-PS (+) and P-BS-PS (+) groups (Fig. 8e). Here, CD8A is linked to neoplasm.