The above results demonstrated that beyond interception of the CXCR4-mediated “seed-soil” metastatic cascade to reduce spontaneous tumor metastasis, escalated CXCR4 clustering by P-BS-CM1 → P-CM2 removed physical barriers by alleviating desmoplasia and reduced immunological barriers by reversing immunosuppression. The gene discussed is CXCR4; the disease is neoplasm.