CXCR4 and neoplasm: Importantly, these results clearly demonstrate the bidirectional functions of P-BS-CM1 → P-PS-CM2 (+) in rejecting disseminated tumor cells through: (1) escalation of CXCR4 clustering to minimize pro-metastatic influence of PMN, and (2) potentiation of ICD-inducing PDT to generate abscopal immunological memory against circulating tumor cells.