CXCR4 and cancer: Consequently, P-BS-CM1 → P-PS-CM2 (+) primed anti-cancer immunity in the local tumor microenvironment, partially through amplified ICD-inducing PDT recruiting CD8+ T cells into the tumor bed, and partially through escalated CXCR4 clustering reducing immunosuppressive Tregs and MDSCs (Supplementary Fig. 21).