Concurrently, nanothread ‘patching’-enabled CXCR4 antagonism consolidates survival pathway interference, hypoxia alleviation and immunosuppression reversal, which potentiates the tumor-localized PDT, thus initiating anti-tumor immune response against the primary tumor while also establishing an abscopal memory effect against disseminated metastasis. The gene discussed is CXCR4; the disease is neoplasm.