CXCR4 and neoplasm: With CXCR4 antagonism upon receptor clustering escalation, superior effect of P-BS-CM1 → P-CM2 is also observed in its ability to disrupt the metastasis cascade by shaping the phenotype of metastatic tumor “seeds”, interrupting the “seed-soil” crosstalk, and attenuating the influence of pro-metastatic PMN “soils” (Fig. 6).