Collectively, during stepwise delivery of two interactable nanothreads (P-BS-CM1 → P-CM2) that self-assemble into supramolecular network via coiled-coil interaction (Fig. 2), we show P-BS-CM1 forms a surface-bound ring pattern surrounding cancer cells through active recognition and multivalent stringing of adjacent CXCR4 (Fig. 3a), and, upon sequential netlike crosslinking, P-CM2 spatially reorganizes CXCR4-anchored Nanothread-1 from uniform distribution to condensed speckles patching on extensive cell-surface area (Fig. 3b). Here, CXCR4 is linked to cancer.