TNF and pancreatic intraductal papillary-mucinous neoplasm: Interestingly, TNFα signaling via NFKβ, EMT, and KRAS signaling were upregulated in high-grade IPMN (Supplementary Figs. S11, and S12, Source Data) compared to Borderline IPMN and, in turn, Borderline IPMN showed increased activation of TNFα signaling compared to LGD IPMN (Supplementary Fig. S13, Source Data) indicating an association with both aggressiveness and dysplasia.