Conversely, while SPDEF expression also increases with dysplasia grade, it exhibits high expression exclusively in Intestinal-type IPMN (Normal Duct, 1.6%; LGD, 7.4%; BR, 30.6%; Gastric, 8%; Intestinal, 35.6%; PB, 4.4%; Fig. 8). The gene discussed is SPDEF; the disease is pancreatic intraductal papillary-mucinous neoplasm.