CIN has been reported to cause cell cycle arrest.333–336 Live-cell imaging of human cells with chromosome missegregation demonstrated that missegregation induces cell cycle arrest in a p53-dependent manner.333–335,337 Known as the “guardian of the genome”, p53 plays crucial role in controlling cell cycle progression.338–341 The tumor suppressive function of p53 is closely related with response to CIN and is critical for determining the fate of cells experiencing CIN.333–335,342–346. The gene discussed is TP53; the disease is cervical squamous intraepithelial neoplasia.