ADCY10 and cervical squamous intraepithelial neoplasia: For example, combining a SAC inhibitor with microtubule-destabilizing drug SKI606 results in the selective killing of tumor cells exhibiting a CIN phenotype.410 Moreover, combining a p38α inhibitor, which interferes with DNA damage response, with taxane-based chemotherapy increased the efficiency of killing breast tumor cells compared to taxanes alone by boosting CIN.358 While they have not yet been used in clinical settings, there are also other compounds that can induce CIN.