KIF18A and cervical squamous intraepithelial neoplasia: For example, a study by Marquis et al., which aims to identify synthetic lethal gene in tumor cells with CIN, has discovered that targeting kinesin family member 18A (KIF18A) is particularly detrimental to aneuploid tumor cells.438 This sensitivity arises from alterations in spindle geometry and microtubule dynamics specific in tumor cell with CIN, which, upon KIF18A knockdown, leads to excessive CIN and reduces tumor cells viability.