PIEZO1 and Intervertebral disk degeneration: These changes can also cause disturbances in matrix metabolism and accelerate the process of intervertebral disc degeneration (IVDD).27,28 There is a positive correlation between changes in the mechanical properties and abnormal changes in the structure and composition of the IVD.29 Besides, Piezo1 is upregulated in degenerated NP samples and Piezo1 activation by mechanical stress can accelerate the senescence of human NPCs and IVDD progression via periostin and self-amplifying loop of NF-kB.30