Iron-dependent ferroptosis is characterized by reduced glutathione levels and increased lipid peroxidation.47,48 Several studies have demonstrated that ferroptosis is involved in neurotoxicity, cancer, renal injury, and iron metabolism-related disorders.49–51 Herein, FAC changed iron metabolism and ferroptosis in NPCs, consistent with previous reports.52 Interestingly, Piezo1 activation significantly increased these effects in a high iron environment, thus significantly increasing iron influx and ferroptosis. Here, PIEZO1 is linked to cancer.