PIEZO1 and renal fibrosis: Piezo1 has been shown to mediate the impact of hydrostatic stress on cell fate determination in mesenchymal stem cells.19–21 Piezo1 also participates in the progression of renal fibrosis, as well as profibrotic changes and small artery remodeling in hypertensive patients.22,23 Moreover, Piezo1 is a mechanical transduction mediator for Ca2+-mediated activation of stiff extracellular matrix (ECM) in nucleus pulposus cells (NPCs).24 Nonetheless, further research is required to determine the potential role of rigid ECM in Piezo1 activation.