While different tau isoforms and mutants are used interchangeably to model AD and other tauopathies, our study adds to the growing body of literature that emphasizes the differences in protein interactions between tau and its mutants, which would suggest that they have different roles in the cell as well as different contributions to disease pathogenesis (21, 76, 77, 78, 100). Here, MAPT is linked to tauopathy.