TNF and Epstein-Barr virus infection: The KEGG analysis showed that the upregulated genes in cMono were enriched in Tuberculosis, lipid and atherosclerosis, Epstein-Barr virus infection, TNF signaling pathway, NF-kB signaling pathway, Toxoplasmosis, IL-17 signaling pathway, Th17 cell differentiation, Legionellosis, and Leishmaniasis (Figure 5D).