AFP and Cirrhosis: In the GSE14520 dataset, tumor size (P=0.002; HR=1.975, 95% CI:1.274-3.060), cirrhosis (P=0.025; HR=4.335, 95% CI: 1.065-17.638), BCLC stage (P<0.001; HR=18.993, 95% CI: 4.419-81.632), TNM stage (P<0.001; HR=3.425, 95% CI: 2.171-5.405), and AFP (P=0.049; HR=1.546, 95% CI: 1.002-2.385) were associated with the OS of HCC, while gender (P=0.018, HR=2.142, 95% CI: 1.120-4.100), TNM stage (P<0.001; HR=2.279, 95% CI: 1.517-3.423), and BCLC stage (P<0.001; HR=6.163, 95% CI: 2.477-15.333) were associated with the RFS of HCC.