In the subgroup analysis stratified by sex, race/ethnicity, liver disease, arthritis, and gout (Table 2), the negative correlation of ALB with bone ALP remained, except for black individuals (β = −1.755, 95%CI: [−3.848, 0.338], P = .103) and patients with gout (β = −0.676, 95%CI: [−2.061, 0.709], P = .340). This evidence concerns the gene ALB and liver disorder.