In the subgroup analysis stratified by sex, race/ethnicity, and liver disease, the negative correlation of ALB with ALP remained for most groups, except in blacks (β = −1.755, 95%CI: [−3.848, 0.338], P = .103) and patients with gout (β = −0.676, 95%CI: [−2.061, 0.709], P = .340). The gene discussed is ALB; the disease is liver disorder.