NR4A1 and neoplasm: Additionally, these CD56dimCD16hi NK cells in the tumor exhibited higher levels of NR4A1 (Table S3, Supplemental Digital Content, http://links.lww.com/MD/L969), a known mediator of T cell dysfunction, which is believed to limit the effectiveness of CAR T cells in solid tumors.[29] Interestingly, our findings also revealed that, the CD56brightCD16lo NK cells within tumors showed increased production of cytokines.