CCL22 and neoplasm: Previous studies have reported that LAMP3+ DCs can attract Treg cells to the tumor area through cytokines.[31] Specifically, CCL17 and CCL22, which bind to CCR4 on the Treg cell membrane, have strong chemotactic activity towards Tregs.[32,33] Interestingly, LAMP3+ DCs in ECC predominantly expressed genes encoding cytokines such as CCL17, CCL19, and CCL22 (Fig. 4D).