Recent immunofluorescence analyses have revealed that LAMP3+ DCs co-localize with NK cells in various types of cancer.[28] The interaction between LAMP3+ DCs and CD56dimCD16hi NK cells through the IL-15-IL-15 receptor and NECTIN2-TIGIT interaction axes has been confirmed by CellPhoneDB analysis.[28] This study found that LAMP3+ DCs express the highest levels of IL15 and NECTIN2 among myeloid cells (Fig. 4D). Here, TIGIT is linked to cancer.