The mechanisms involved in AMPK, Nrf2/ARE, JNK, miR-211, SIRT1/p53, etc, mainly include: controlling blood sugar, antioxidant, anti-inflammatory, inhibiting cell apoptosis, inhibiting autophagy, improving metabolic syndrome, etc. Each target is interconnected and jointly affects, exerting its protective effect on neuropathy. This evidence concerns the gene MAPK8 and metabolic syndrome.