The mechanisms involved in AMPK, Nrf2/ARE, JNK, miR-211, SIRT1/p53, etc, mainly include: controlling blood sugar, antioxidant, anti-inflammatory, inhibiting cell apoptosis, inhibiting autophagy, improving metabolic syndrome, etc. Each target is interconnected and jointly affects, exerting its protective effect on neuropathy. This evidence concerns the gene TP53 and neuropathy.