In that regard, it is intriguing that transient Plk4 expression delays onset of T cell lymphomas driven by IR damage (Fig. 4C) in a PIDDosome-dependent manner, as this phenotype is abrogated when Raidd (Fig. 7A) or Pidd1 is lacking (fig. The gene discussed is PIDD1; the disease is T-cell non-Hodgkin lymphoma.