AGT and hypertensive disorder: Increased F/B ratio is regarded as a marker of gut dysbiosis and is consistently reported both in genetic and induced hypertensive rat models including the SHR (Yang et al., 2015; Hsu et al., 2020; Li et al., 2020), DSS rats (Mell et al., 2015; Waghulde et al., 2018) high-fat diet fed rats (Hsu et al., 2019), NG-nitro-l-arginine methyl ester (l-NAME) treated rats (Robles-Vera et al., 2018) and angiotensin II induced HTN rats (Yang et al., 2015).