IFNA1 and systemic lupus erythematosus: However, there are conflicting reports regarding the effectiveness of stratifying patients based on IFN gene signatures in clinical trials of type I IFN inhibition (Khamashta et al., 2016; Furie et al., 2017; Morand et al., 2020), demonstrating the complexity of the type I IFN response in SLE and identifying the need for additional stratification approaches.