RAS-opathies also include neurofibromatosis type 1, Noonan syndrome with multiple lentigines, Noonan syndrome-like disorder with loose anagen hair, Noonan syndrome-like disorder with or without juvenile myelomonocytic leukaemia, capillary malformation-arteriovenous malformation syndrome, Costello syndrome, cardio-facio-cutaneous syndrome, SYNGAP1-related intellectual disability and Legius syndrome. This evidence concerns the gene SYNGAP1 and cardiofaciocutaneous syndrome.