MAP3K5 and Stroke: Within hours of a stroke or modeled laser-ablated vessel, microglia begin their journey toward the affected region (Ahn et al., 2018; Lubart et al., 2021; Boghozian et al., 2023), which is prompted by a variety of signaling molecules, including fractalkine (Cao et al., 2019) and the purine, ATP (Davalos et al., 2005), extracellular peroxiredoxin (prx6) (Kuang et al., 2014), several Rho guanosine triphosphate hydrolyases (GTPases), like Rac, Cdc42, and Rho (Choi et al., 2011), CXCL12 (Huang et al., 2017), and apoptosis signal-regulating kinase 1 (ASK1) (Cheon et al., 2017).