However, B-cell-deficient ischemic stroke mice did not show any improvement in neurological function, whereas B-cell overshoot attenuated the extent of cerebral infarction and improved neurological function, which may be related to the secretion of the anti-inflammatory cytokine IL-10 (Yilmaz et al., 2006; Doyle et al., 2015). The gene discussed is IL10; the disease is ischemic stroke.