Schuhmann et al. found that drug depletion of B-cells did not alter infarct volume or functional recovery on day 1 after stroke; similarly, lack of circulating B-cells did not affect recovery after stroke in the JHD−/− and Rag1−/− mouse models, suggesting that B-cells are not a major pathophysiologic factor and have a limited effect on lesion volume and functional recovery (Schuhmann et al., 2017). The gene discussed is RAG1; the disease is stroke disorder.