Korf et al. explored the role of B-cells with high expression of CD11b in the immune response after stroke and found that these cells, which were increased in the brains of aged and post-stroke mice, were able to modulate the phenotype and increase the phagocytosis of microglial cells, which in turn had an impact on neuroinflammation after stroke, suggesting that B-cells have a distinctive role for specific subpopulations in both the acute and chronic phases of the immune response after stroke (Korf et al., 2022). Here, ITGAM is linked to stroke disorder.