Stroke-induced peripheral inflammatory response plays an important role in determining neurological prognosis, and Katie et al. found that the peripheral inflammatory response peaks 4 h after stroke, earlier than the 24 h peak of cerebral inflammation, and is mainly characterized by an increase in the chemokine CXCL-1 and the pro-inflammatory cytokines interleukin-6 and IFN-γ (Chapman et al., 2009). The gene discussed is IL6; the disease is Stroke.