The abundance of the ferritinophagy cargo receptor NCOA4 was increased, while the abundance of the iron storage protein FTH1 and the ferroptosis key suppressor GPX4 (Yoshida et al., 2019; Yan et al., 2021) was significantly decreased in PCOS patients (Fig. 1E–I). This evidence concerns the gene PROS1 and polycystic ovary syndrome.