Activated T cells proliferate and migrate to the tumor site, where their CTL activity causes tumor cell death, further generating antigens and maintaining the tumor-specific T cell induction and anti-tumor function.51 When the CTLs successfully interact with the MHC-I molecule of the target tumor cell, molecules like perforins and granzymes kill the tumor cell through the formation of pores in the membrane of the target cell. The gene discussed is PRF1; the disease is neoplasm.