Although targeting T cells for cancer immunotherapy has been extensively described in previous work, only several studies suggest a positive correlation between the presence of B cells in the TME and improved prognosis in various cancer types.62-64 Regulatory B (Breg) cells indirectly suppress immune responses by secreting the following cytokines: IL-10, IL-35, and TGF-β. This evidence concerns the gene TGFB1 and cancer.