To investigate whether the cardioprotective effect mediated by DNA-PKcs deficiency is linked to improved immune reactions, western blots were employed to observe changes in TLR4, NLR family pyrin domain containing 3 (NLRP3), and caspase-1 in heart tissues and CMECs. The gene discussed is TLR4; the disease is hyperinsulinemic hypoglycemia, familial, 4.