In a study on biomarkers related to inflammatory endotypes of CRS patients without nasal polyps (CRSsNP), SerpinB2 and SerpinB10 were found to be significantly increased in T2 CRSsNP, which can be regulated by IL-13 and STAT6 [10]. The gene discussed is SERPINB10; the disease is chronic rhinosinusitis without nasal polyps.