In a study on biomarkers related to inflammatory endotypes of CRS patients without nasal polyps (CRSsNP), SerpinB2 and SerpinB10 were found to be significantly increased in T2 CRSsNP, which can be regulated by IL-13 and STAT6 [10]. This evidence concerns the gene SERPINB2 and chronic rhinosinusitis without nasal polyps.