While our findings demonstrated the inhibitory role of SerpinB3/B4 on CXCL8/IL-8 expression in nasal epithelial cells, it is important to note that CXCL8/IL-8 levels have been reported to be elevated in CRSwNP mucosa, particularly in cases with neutrophilic inflammation [47]. This evidence concerns the gene SERPINB3 and chronic rhinosinusitis with nasal polyps.