CD8A and immune system disorder: Besides, PWH on suppressive ART generally presents persistently elevated CD8+ T cell counts and a low CD4+/CD8+ ratio, linked to a higher immune dysfunction (immune activation, inflammation, immunosenescence, among others), viral reservoir size, aging, comorbidities, and mortality (Lu et al., 2015; Zicari et al., 2019; Chen et al., 2022).