CD4 and HIV infectious disease: Gelpi et al. (2018) have also reported an independent association between HIV infection and hypertension, hypertriglyceridemia, and abdominal obesity. Nevertheless, they included PWH with a CD4+/CD8+ ratio <1, which could play a significant role in the differences. However, to our knowledge, no previous studies have evaluated metabolomic dysregulation in PWH on long-term ART with CD4+/CD8+ ≥1.