IFNG and cancer: However, it was unclear whether the and/or case, single positive, or double positive is more useful in controlling cancer, so we compared them in this study based on four criteria: IFNγ+ and/or 4-1BB+, IFNγ+, 4-1BB+, and double-positive (IFNγ+4-1BB+) (Figures 2A, B).