In lung cancer, correlations between the cytotoxic activity of tumor-infiltrating lymphocytes (TILs) and that of peripheral blood mononuclear cell (PBMC)-derived T cells have been reported, as have correlations between the cytotoxic activity of TILs and the percentage of PBMC-derived effector memory re-expressing CD45RA CD8+ T cells. The gene discussed is CD8A; the disease is neoplasm.