No impact of genetic predisposition to psoriasis on any of the obesity or lipidemic traits was observed in our reverse-directional MR analysis (BMI Beta=-0.009, 95%CI=-0.019-0.001; WHR Beta=-0.002, 95%CI=-0.011-0.008; WHRadjBMI Beta=0.002, 95%CI=-0.008-0.012; apoA1 Beta=0, 95%CI=-0.022-0.021; apoB Beta=0.006, 95%CI=-0.007-0.019; apoE Beta=-0.046, 95%CI=-0.119-0.027; HDL Beta=-0.001, 95%CI=-0.022-0.021; LDL Beta=0.007, 95%CI=-0.006-0.02; TG Beta=-0.002, 95%CI=-0.02-0.016; TC Beta=0.013, 95%CI=-0.009-0.034) (Figure 3; Supplementary Table 17). This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.