In contrast, we did not observe any significant association between lipidemic traits and the risk of psoriasis, as all effect sizes were close to 1.00 (apoA1, IVW OR=1.073, 95%CI=0.934-1.233; apoB, IVW OR=1.051, 95%CI=0.968-1.142; apoE, IVW OR=1.051, 95%CI=0.973-1.135; HDL, IVW OR=1.054, 95%CI=0.943-1.179; LDL, IVW OR=1.068, 95%CI=0.972-1.175; TC, IVW OR=1.096, 95%CI=0.989-1.213; TG, IVW OR=0.954, 95%CI=0.875-1.04). This evidence concerns the gene APOE and psoriasis.