Because we only obtained one clonal MKD-MA cell line, we stably expressed WT MVK cDNA in the MKD-MA THP-1 cells (THP-1 MKD-MA*MK) to ascertain that any metabolic, immunological and cellular changes that occur in this MKD-MA cell line are caused by the introduced MK deficiency and not by an off-target event introduced by the CRISPR/Cas9 editing. Here, MVK is linked to hyperinsulinemic hypoglycemia, familial, 4.