(33) studied the expression of several antigens in tumor cells from 7 GBM patients, before and after a single infusion of EGFR-targeted CAR-T cells, observing in all of them a significant decrease in EGFR expression, but an important increase in several other antigens with known immunosuppressor functions (CD8, GRZMB, CD25, IDO1, PDL1, and FoxP3). This evidence concerns the gene CD8A and neoplasm.