Suppress YAP1 function and hinder the progression of hepatocellular; Inhibit YAP1 by disrupting YAP1-TEAD interactions; Inhibit the growth of HCC through apoptosis mediated by mitochondrial dysfunction; Decrease the percentage of PD-1+CD8+T cells in the spleen of mice with liver tumor and increase the rate of PD-1-CD8+T cells in the peripheral blood of mice. This evidence concerns the gene PDCD1 and hepatocellular carcinoma.