In HCC, the interaction between the ETS transcription factor 4 (ETV4) and YAP1 activates the expression of CXCL1 and CC motif chemokine ligand 2(CCL2), leading to the infiltration of MDSCs and TAM while also down-regulating the number of T cells and NK cells. This evidence concerns the gene CCL2 and hepatocellular carcinoma.