CCL2 and hepatocellular carcinoma: The transcriptional activity of YAP1/TEAD recruits TICAM, in which YAP1/TEAD1 directly binds to the promoter of CCL2. Oncogenes such as AKT/EGFR activate YAP1 in HCC, upregulate CCL2 expression, and recruit TICAM to promote the survival and tumorigenesis of TIC (46).