Activated YAP1 upregulates the secretion of IL-6 and TNF-α from tumor cells, as well as colony-stimulating factor 1-3 (CSF1-3), CXC motif chemokine ligand 5(CXCL5), PGE2, COX2, and other factors that recruit MDSCs (84). Here, IL6 is linked to neoplasm.