TNF and Granuloma: considers the progression of sarcoidosis in terms of a granuloma radius represented as a conglomerate of Mφ, Th1, Treg and Th17 cells, which affect each other through a network of cytokines and chemokines (IL-2, IL-10, IL-12, IL-13, chemokine ligand 20, IFN-γ, TNF-α and TGF-β) (59, 60).