For example, Lo and colleagues focused on aspects of T-cell polarization during the initial steps of the inflammatory processes in IBD, by modeling Th1, Th2 and Treg population densities as a function of concentrations of transcription factors (T-bet, Gata3 and Foxp3) and four cytokines (IFN-γ, IL-4, TGF-β and IL-2) (35). Here, IL4 is linked to inflammatory bowel disease.