The monoclonal antibody 7C6 inhibits the shedding of MICA/B, and thus increases the density of MICA/B proteins on the surface of tumor cells (45) Although we saw no reduction in efficacy of VHHA1-DM1 on MICA+ cells upon addition of sMICA to the medium, the combination of anti-MICA nanobody adducts with the 7C6 antibody might therefore be therapeutically more attractive than either treatment alone. The gene discussed is MICA; the disease is neoplasm.